Synthesis and Pharmacological Evaluation of (+)-Usnic Acid Derivatives as Hypoglycemic Agents by unknow
Author:unknow
Format: pdf
Tags: Usnic acid is produced by lichens and exhibits different biological properties, including hypoglycemic ones. However, this effect becomes noticeable only at relatively high doses, something that may lead to some adverse effects. The chemical modification of the molecule is able to enhance its safety profile and its hypoglycemic properties. We synthesized six enamine derivatives of (+)-usnic acid, and two of them are novel. All compounds were evaluated for the hypoglycemic effect after oral introduction in mice with alloxan-induced diabetes mellitus at a dose of 50 mg/kg. The derivative containing a 4-trifluoromethylphenyl fragment showed the most pronounced hypoglycemic effect, which was detected starting from sixth day of the experiment. Also, OGTT was performed in mice without alteration of glucose metabolism (C57BL/6), which showed no hypoglycemic effect after oral introduction of all studied compounds., usnic acid; enamines; hypoglycemic action; diabetes mellitus
Download
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.
Administration & Medicine Economics | Allied Health Professions |
Basic Sciences | Dentistry |
History | Medical Informatics |
Medicine | Nursing |
Pharmacology | Psychology |
Research | Veterinary Medicine |
The Poisoner's Handbook by Deborah Blum(1665)
Bottle of Lies by Katherine Eban(1476)
The Vaccine Race by Meredith Wadman(1354)
Missing Microbes by Martin Blaser(1318)
Mycelium Running: How Mushrooms Can Help Save the World by Paul Stamets(1290)
Pharmacy Practice and The Law by Richard Abood(1256)
The Doors of Perception and Heaven and Hell by Aldous Huxley & Aldous Huxley(1239)
28 Seconds by Michael Bryant(1204)
Decisive by Chip Heath(1202)
Steroids: History, Science, and Issues by Standora Joan E.; Bogomolnik Alex; Slugocki Malgorzata(1196)
McGraw-Hill Nurses Drug Handbook by Patricia Schull(1185)
Ganja Yoga by Dee Dussault(1175)
What's Making Our Children Sick? by Michelle Perro(1157)
The Doors of Perception: Heaven and Hell (thINKing Classics) by Aldous Huxley(1151)
Complete Guide to Prescription & Nonprescription Drugs 2014 by H. Winter Griffith(1076)
Stealing Fire: How Silicon Valley, the Navy SEALs, and Maverick Scientists Are Revolutionizing the Way We Live and Work by Steven Kotler & Jamie Wheal(1075)
Trip by Tao Lin(1046)
Anatomy of an Epidemic by Robert Whitaker(975)
Cannabis for Chronic Pain by Rav Ivker(955)